Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. H...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Defour, J-P, Leroy, E, Dass, S, Balligand, T, Levy, G, Brett, IC, Papadopoulos, N, Mouton, C, Genet, L, Pecquet, C, Staerk, J, Smith, SO, Constantinescu, SN
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: eLife Sciences Publications 2023

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