Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. H...

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Detalles Bibliográficos
Main Authors: Defour, J-P, Leroy, E, Dass, S, Balligand, T, Levy, G, Brett, IC, Papadopoulos, N, Mouton, C, Genet, L, Pecquet, C, Staerk, J, Smith, SO, Constantinescu, SN
Formato: Journal article
Idioma:English
Publicado: eLife Sciences Publications 2023

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