Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. H...
| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
eLife Sciences Publications
2023
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