Design, synthesis, and biological evaluation of 2-hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 antagonist and its comparison to available small molecular PD-L1 inhibitors

<p>In search of a potent small molecular PD-L1 inhibitor, we designed and synthesized a compound based on a 2-hydroxy-4-phenylthiophene-3-carbonitrile moiety. Ligand’s performance was tested in vitro and compared side-by-side with a known PD-L1 antagonist with a proven bioactivity BM...

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Bibliografski detalji
Glavni autori:	Ważyńska, MA, Butera, R, Requesens, M, Plat, A, Zarganis-Tzitzikas, T, Neochoritis, CG, Plewka, J, Skalniak, L, Kocik-Krol, J, Musielak, B, Magiera-Mularz, K, Rodriguez, I, Blok, SN, de Bruyn, M, Nijman, HW, Elsinga, PH, Holak, TA, Dömling, A
Format:	Journal article
Jezik:	English
Izdano:	American Chemical Society 2023

Design, synthesis, and biological evaluation of 2-hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 antagonist and its comparison to available small molecular PD-L1 inhibitors

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