Design, synthesis, and biological evaluation of 2-hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 antagonist and its comparison to available small molecular PD-L1 inhibitors

Design, synthesis, and biological evaluation of 2-hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 antagonist and its comparison to available small molecular PD-L1 inhibitors

<p>In search of a potent small molecular PD-L1 inhibitor, we designed and synthesized a compound based on a 2-hydroxy-4-phenylthiophene-3-carbonitrile moiety. Ligand&rsquo;s performance was tested in vitro and compared side-by-side with a known PD-L1 antagonist with a proven bioactivity BM...

Full description

Bibliographic Details
Main Authors: Ważyńska, MA, Butera, R, Requesens, M, Plat, A, Zarganis-Tzitzikas, T, Neochoritis, CG, Plewka, J, Skalniak, L, Kocik-Krol, J, Musielak, B, Magiera-Mularz, K, Rodriguez, I, Blok, SN, de Bruyn, M, Nijman, HW, Elsinga, PH, Holak, TA, Dömling, A
Format: Journal article
Language:English
Published: American Chemical Society 2023

Similar Items

Similar Items