A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol.
Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoper...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797075139255336960 |
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| author | Brierley, R Pike, K Miles, A Wordsworth, S Stokes, E Mumford, A Cohen, A Angelini, G Murphy, G Rogers, C Reeves, B |
| author_facet | Brierley, R Pike, K Miles, A Wordsworth, S Stokes, E Mumford, A Cohen, A Angelini, G Murphy, G Rogers, C Reeves, B |
| author_sort | Brierley, R |
| collection | OXFORD |
| description | Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study. |
| first_indexed | 2024-03-06T23:46:06Z |
| format | Journal article |
| id | oxford-uuid:70f23339-d515-47bb-9bb3-de4c0c04815a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:46:06Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:70f23339-d515-47bb-9bb3-de4c0c04815a2022-03-26T19:40:36ZA multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70f23339-d515-47bb-9bb3-de4c0c04815aEnglishSymplectic Elements at Oxford2014Brierley, RPike, KMiles, AWordsworth, SStokes, EMumford, ACohen, AAngelini, GMurphy, GRogers, CReeves, BThresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study. |
| spellingShingle | Brierley, R Pike, K Miles, A Wordsworth, S Stokes, E Mumford, A Cohen, A Angelini, G Murphy, G Rogers, C Reeves, B A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol. |
| title | A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol. |
| title_full | A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol. |
| title_fullStr | A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol. |
| title_full_unstemmed | A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol. |
| title_short | A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: study protocol. |
| title_sort | multi centre randomised controlled trial of transfusion indication threshold reduction on transfusion rates morbidity and healthcare resource use following cardiac surgery study protocol |
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