The genetic epidemiology of spontaneous endometriosis in the rhesus monkey.
The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenot...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1826278586060898304 |
|---|---|
| author | Zondervan, K Cardon, L Desrosiers, R Hyde, D Kemnitz, J Mansfield, K Roberts, J Scheffler, J Weeks, D Kennedy, S |
| author_facet | Zondervan, K Cardon, L Desrosiers, R Hyde, D Kemnitz, J Mansfield, K Roberts, J Scheffler, J Weeks, D Kennedy, S |
| author_sort | Zondervan, K |
| collection | OXFORD |
| description | The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. Since endometriosis develops spontaneously in the rhesus monkey (Macaca mulatta) and the tissue is morphologically identical to its human counterpart, this population provides a unique opportunity to conduct such studies in this condition. |
| first_indexed | 2024-03-06T23:46:08Z |
| format | Journal article |
| id | oxford-uuid:70f595d7-4735-4d17-b4c4-163dad765b1c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:46:08Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:70f595d7-4735-4d17-b4c4-163dad765b1c2022-03-26T19:40:45ZThe genetic epidemiology of spontaneous endometriosis in the rhesus monkey.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70f595d7-4735-4d17-b4c4-163dad765b1cEnglishSymplectic Elements at Oxford2002Zondervan, KCardon, LDesrosiers, RHyde, DKemnitz, JMansfield, KRoberts, JScheffler, JWeeks, DKennedy, SThe etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. Since endometriosis develops spontaneously in the rhesus monkey (Macaca mulatta) and the tissue is morphologically identical to its human counterpart, this population provides a unique opportunity to conduct such studies in this condition. |
| spellingShingle | Zondervan, K Cardon, L Desrosiers, R Hyde, D Kemnitz, J Mansfield, K Roberts, J Scheffler, J Weeks, D Kennedy, S The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. |
| title | The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. |
| title_full | The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. |
| title_fullStr | The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. |
| title_full_unstemmed | The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. |
| title_short | The genetic epidemiology of spontaneous endometriosis in the rhesus monkey. |
| title_sort | genetic epidemiology of spontaneous endometriosis in the rhesus monkey |
| work_keys_str_mv | AT zondervank thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT cardonl thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT desrosiersr thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT hyded thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT kemnitzj thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT mansfieldk thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT robertsj thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT schefflerj thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT weeksd thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT kennedys thegeneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT zondervank geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT cardonl geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT desrosiersr geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT hyded geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT kemnitzj geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT mansfieldk geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT robertsj geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT schefflerj geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT weeksd geneticepidemiologyofspontaneousendometriosisintherhesusmonkey AT kennedys geneticepidemiologyofspontaneousendometriosisintherhesusmonkey |