Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency.
Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797075142945275904 |
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| author | Aslam, A Misbah, SA Talbot, K Chapel, H |
| author_facet | Aslam, A Misbah, SA Talbot, K Chapel, H |
| author_sort | Aslam, A |
| collection | OXFORD |
| description | Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae. |
| first_indexed | 2024-03-06T23:46:09Z |
| format | Journal article |
| id | oxford-uuid:70f7e8b7-ec3a-415c-a398-b1b0e3b995d9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:46:09Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:70f7e8b7-ec3a-415c-a398-b1b0e3b995d92022-03-26T19:40:40ZVitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:70f7e8b7-ec3a-415c-a398-b1b0e3b995d9EnglishSymplectic Elements at Oxford2004Aslam, AMisbah, SATalbot, KChapel, HVitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae. |
| spellingShingle | Aslam, A Misbah, SA Talbot, K Chapel, H Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. |
| title | Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. |
| title_full | Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. |
| title_fullStr | Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. |
| title_full_unstemmed | Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. |
| title_short | Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. |
| title_sort | vitamin e deficiency induced neurological disease in common variable immunodeficiency two cases and a review of the literature of vitamin e deficiency |
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