Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders

Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders

Neuromyelitis optica spectrum disorders (NMOSDs) are caused by immunoglobulin G (IgG) autoantibodies directed against the water channel aquaporin-4 (AQP4). In NMOSDs, discrete clinical relapses lead to disability and are robustly prevented by the anti-CD20 therapeutic rituximab; however, its mechani...

Podrobná bibliografie
Hlavní autoři:	Damato, V, Theorell, J, Al-Diwani, A, Kienzler, A-K, Makuch, M, Sun, B, Handel, A, Akdeniz, D, Berretta, A, Ramanathan, S, Fower, A, Whittam, D, Gibbons, E, McGlashan, N, Green, E, Huda, S, Woodhall, M, Palace, J, Sheerin, F, Waters, P, Leite, MI, Jacob, A, Irani, SR
Médium:	Journal article
Jazyk:	English
Vydáno:	National Academy of Sciences 2022

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