Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examin...

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Detaylı Bibliyografya
Asıl Yazarlar: Novelli, MR, Williamson, J, Tomlinson, I, Elia, G, Hodgson, S, Talbot, I, Bodmer, W, Wright, N
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 1996
Diğer Bilgiler
Özet:It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.

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