Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examin...
| Prif Awduron: | , , , , , , , |
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| Fformat: | Journal article |
| Iaith: | English |
| Cyhoeddwyd: |
1996
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| _version_ | 1826278600699019264 |
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| author | Novelli, MR Williamson, J Tomlinson, I Elia, G Hodgson, S Talbot, I Bodmer, W Wright, N |
| author_facet | Novelli, MR Williamson, J Tomlinson, I Elia, G Hodgson, S Talbot, I Bodmer, W Wright, N |
| author_sort | Novelli, MR |
| collection | OXFORD |
| description | It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin. |
| first_indexed | 2024-03-06T23:46:21Z |
| format | Journal article |
| id | oxford-uuid:710a2f24-f9bd-461c-973f-308d8ced9638 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:46:21Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:710a2f24-f9bd-461c-973f-308d8ced96382022-03-26T19:41:09ZPolyclonal origin of colonic adenomas in an XO/XY patient with FAP.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:710a2f24-f9bd-461c-973f-308d8ced9638EnglishSymplectic Elements at Oxford1996Novelli, MRWilliamson, JTomlinson, IElia, GHodgson, STalbot, IBodmer, WWright, NIt is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin. |
| spellingShingle | Novelli, MR Williamson, J Tomlinson, I Elia, G Hodgson, S Talbot, I Bodmer, W Wright, N Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| title | Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| title_full | Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| title_fullStr | Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| title_full_unstemmed | Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| title_short | Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| title_sort | polyclonal origin of colonic adenomas in an xo xy patient with fap |
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