Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examin...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Novelli, MR, Williamson, J, Tomlinson, I, Elia, G, Hodgson, S, Talbot, I, Bodmer, W, Wright, N
Format:	Journal article
Sprache:	English
Veröffentlicht:	1996

Ähnliche Einträge

The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
von: Leedham, S, et al.
Veröffentlicht: (2006)

Location in the large bowel influences the APC mutations observed in FAP adenomas.
von: Will, O, et al.
Veröffentlicht: (2010)

Using somatic APC mutations as clonal markers to demonstrate polyclonality in colonic polyps
von: Leedham, S, et al.
Veröffentlicht: (2007)

Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
von: Preston, S, et al.
Veröffentlicht: (2003)

The genetics of FAP and FAP-like syndromes.
von: Lipton, L, et al.
Veröffentlicht: (2006)

Top-down or bottom-up morphogenesis of colorectal adenomas: Competing management structures in the origins of colonic neoplasia
von: Preston, S, et al.
Veröffentlicht: (2003)

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
von: Thirlwell, C, et al.
Veröffentlicht: (2010)

Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.
von: Cheng, T, et al.
Veröffentlicht: (2014)

Mosaic Turner Variant Adult Female Presenting with XO/XY Karyotype
von: Sigin George, et al.
Veröffentlicht: (2023-07-01)

Evolutionary history of adenomas to colorectal cancer in FAP families
von: Cuiping Yang, et al.
Veröffentlicht: (2024-07-01)

let-7e downregulation characterizes early phase colonic adenoma in APCMin/+ mice and human FAP subjects.
von: Annalisa Contursi, et al.
Veröffentlicht: (2021-01-01)

Top down or bottom up morphogenesis of colorectal adenomas: Competing management structures in the origins of colorectal neoplasia
von: Preston, S, et al.
Veröffentlicht: (2003)

Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence
von: Ihab Shafek Atta, et al.
Veröffentlicht: (2016-01-01)

Significance of Apoptosis in the Process of Tumorigenesis in Colorectal Mucosa and Adenomas in FAP Patients
von: Hildegard Weiß, et al.
Veröffentlicht: (1997-01-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
von: Bodmer, W
Veröffentlicht: (1999)

Surgical treatment of familial adenomatous polyposis (FAP) of the colon on children.
von: M.U. Ismayilov, et al.
Veröffentlicht: (2024-01-01)

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.
von: Preston, S, et al.
Veröffentlicht: (2008)

Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth
von: Wataru Yamazaki, et al.
Veröffentlicht: (2021-12-01)

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
von: Beck, N, et al.
Veröffentlicht: (1997)

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.
von: Suraweera, N, et al.
Veröffentlicht: (2007)

K-ras2 Activation and Genome Instability Increase Proliferation and Size of FAP Adenomas
von: Anna Rapallo, et al.
Veröffentlicht: (1999-01-01)

The mutation rate and cancer.
von: Tomlinson, I, et al.
Veröffentlicht: (1996)

APC mutations are sufficient for the growth of early colorectal adenomas.
von: Lamlum, H, et al.
Veröffentlicht: (2000)

Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity.
von: Tomlinson, I, et al.
Veröffentlicht: (1997)

Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability.
von: Ilyas, M, et al.
Veröffentlicht: (1996)

XO /
von: Deaver, Jeffery, author
Veröffentlicht: (2012)

Patch size in the human colon confounds the assessment of tumour clonality using X chromosome-linked markers
von: Novelli, M, et al.
Veröffentlicht: (2002)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
von: Thirlwell, C, et al.
Veröffentlicht: (2007)

Top down or bottom up: competing management strategies in the histogenesis of colorectal adenomas
von: Wong, R, et al.
Veröffentlicht: (2002)

The XY gene hypothesis of psychosis: origins and current status.
von: Crow, T
Veröffentlicht: (2013)

Molecular genetics of colon cancer.
von: Tomlinson, I, et al.
Veröffentlicht: (1997)

Molecular characteristics of serrated adenomas of the colorectum.
von: Sawyer, E, et al.
Veröffentlicht: (2002)

APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.
von: Latchford, A, et al.
Veröffentlicht: (2007)

Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients
von: Wang, J, et al.
Veröffentlicht: (2013)

On the mapping xy→(xy)n in an associative ring
von: Scott J. Beslin, et al.
Veröffentlicht: (2004-01-01)

Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.
von: Novelli, MR, et al.
Veröffentlicht: (1999)

Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression
von: Victor V. Pleshkan, et al.
Veröffentlicht: (2023-07-01)

Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.
von: Hao, X, et al.
Veröffentlicht: (1997)

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
von: Tomlinson, I, et al.
Veröffentlicht: (1999)

Dataset on FAP-induced emergence of spontaneous metastases and on the preparation of activatable FAP-targeting immunoliposomes to detect the metastases
von: Felista L. Tansi, et al.
Veröffentlicht: (2016-12-01)