Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examin...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Novelli, MR, Williamson, J, Tomlinson, I, Elia, G, Hodgson, S, Talbot, I, Bodmer, W, Wright, N
Natura:	Journal article
Lingua:	English
Pubblicazione:	1996

Documenti analoghi

The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
di: Leedham, S, et al.
Pubblicazione: (2006)

Location in the large bowel influences the APC mutations observed in FAP adenomas.
di: Will, O, et al.
Pubblicazione: (2010)

Using somatic APC mutations as clonal markers to demonstrate polyclonality in colonic polyps
di: Leedham, S, et al.
Pubblicazione: (2007)

Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
di: Preston, S, et al.
Pubblicazione: (2003)

The genetics of FAP and FAP-like syndromes.
di: Lipton, L, et al.
Pubblicazione: (2006)

Top-down or bottom-up morphogenesis of colorectal adenomas: Competing management structures in the origins of colonic neoplasia
di: Preston, S, et al.
Pubblicazione: (2003)

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
di: Thirlwell, C, et al.
Pubblicazione: (2010)

Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.
di: Cheng, T, et al.
Pubblicazione: (2014)

Mosaic Turner Variant Adult Female Presenting with XO/XY Karyotype
di: Sigin George, et al.
Pubblicazione: (2023-07-01)

Evolutionary history of adenomas to colorectal cancer in FAP families
di: Cuiping Yang, et al.
Pubblicazione: (2024-07-01)

let-7e downregulation characterizes early phase colonic adenoma in APCMin/+ mice and human FAP subjects.
di: Annalisa Contursi, et al.
Pubblicazione: (2021-01-01)

Top down or bottom up morphogenesis of colorectal adenomas: Competing management structures in the origins of colorectal neoplasia
di: Preston, S, et al.
Pubblicazione: (2003)

Thyroid, Renal, and Breast Carcinomas, Chondrosarcoma, Colon Adenomas, and Ganglioneuroma: A New Cancer Syndrome, FAP, or Just Coincidence
di: Ihab Shafek Atta, et al.
Pubblicazione: (2016-01-01)

Significance of Apoptosis in the Process of Tumorigenesis in Colorectal Mucosa and Adenomas in FAP Patients
di: Hildegard Weiß, et al.
Pubblicazione: (1997-01-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
di: Bodmer, W
Pubblicazione: (1999)

Surgical treatment of familial adenomatous polyposis (FAP) of the colon on children.
di: M.U. Ismayilov, et al.
Pubblicazione: (2024-01-01)

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.
di: Preston, S, et al.
Pubblicazione: (2008)

Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth
di: Wataru Yamazaki, et al.
Pubblicazione: (2021-12-01)

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
di: Beck, N, et al.
Pubblicazione: (1997)

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.
di: Suraweera, N, et al.
Pubblicazione: (2007)

K-ras2 Activation and Genome Instability Increase Proliferation and Size of FAP Adenomas
di: Anna Rapallo, et al.
Pubblicazione: (1999-01-01)

The mutation rate and cancer.
di: Tomlinson, I, et al.
Pubblicazione: (1996)

APC mutations are sufficient for the growth of early colorectal adenomas.
di: Lamlum, H, et al.
Pubblicazione: (2000)

Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity.
di: Tomlinson, I, et al.
Pubblicazione: (1997)

Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability.
di: Ilyas, M, et al.
Pubblicazione: (1996)

XO /
di: Deaver, Jeffery, author
Pubblicazione: (2012)

Patch size in the human colon confounds the assessment of tumour clonality using X chromosome-linked markers
di: Novelli, M, et al.
Pubblicazione: (2002)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
di: Thirlwell, C, et al.
Pubblicazione: (2007)

Top down or bottom up: competing management strategies in the histogenesis of colorectal adenomas
di: Wong, R, et al.
Pubblicazione: (2002)

The XY gene hypothesis of psychosis: origins and current status.
di: Crow, T
Pubblicazione: (2013)

Molecular genetics of colon cancer.
di: Tomlinson, I, et al.
Pubblicazione: (1997)

Molecular characteristics of serrated adenomas of the colorectum.
di: Sawyer, E, et al.
Pubblicazione: (2002)

APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.
di: Latchford, A, et al.
Pubblicazione: (2007)

Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients
di: Wang, J, et al.
Pubblicazione: (2013)

On the mapping xy→(xy)n in an associative ring
di: Scott J. Beslin, et al.
Pubblicazione: (2004-01-01)

Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.
di: Novelli, MR, et al.
Pubblicazione: (1999)

Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression
di: Victor V. Pleshkan, et al.
Pubblicazione: (2023-07-01)

Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.
di: Hao, X, et al.
Pubblicazione: (1997)

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
di: Tomlinson, I, et al.
Pubblicazione: (1999)

Dataset on FAP-induced emergence of spontaneous metastases and on the preparation of activatable FAP-targeting immunoliposomes to detect the metastases
di: Felista L. Tansi, et al.
Pubblicazione: (2016-12-01)