Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40...

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Main Authors: Cheng, T, Thompson, D, Painter, J, O'Mara, T, Gorman, M, Martin, L, Palles, C, Jones, A, Buchanan, D, Ko Win, A, Hopper, J, Jenkins, M, Lindor, N, Newcomb, P, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Giles, G, Pharoah, P, Peto, J, Cox, A, Swerdlow, A, Couch, F, Cunningham, J, Goode, E, Winham, S, Lambrechts, D, Fasching, P, Burwinkel, B, Brenner, H, Brauch, H, Chang-Claude, J, Salvesen, H, Kristensen, V, Darabi, H, Li, J, Liu, T, Lindblom, A, Hall, P, de Polanco, M, Sans, M, Carracedo, A, Castellvi-Bel, S, Rojas-Martinez, A, Aguiar Jnr, S, Teixeira, M, Dunning, A, Dennis, J, Otton, G, Proietto, T, Holliday, E, Attia, J, Ashton, K, Scott, R, McEvoy, M, Dowdy, S, Fridley, B, Werner, H, Trovik, J, Njolstad, T, Tham, E, Mints, M, Runnebaum, I, Hillemanns, P, Dörk, T, Amant, F, Schrauwen, S, Hein, A, Beckmann, M, Ekici, A, Czene, K, Meindl, A, Bolla, M, Michailidou, K, Tyrer, J, Wang, Q, Ahmed, S, Healey, C, Shah, M, Annibali, D, Depreeuw, J, Al-Tassan, N, Harris, R, Meyer, B, Whiffin, N, Hosking, F, Kinnersley, B, Farrington, S, Timofeeva, M, Tenesa, A, Campbell, H, Haile, R, Hodgson, S, Carvajal-Carmona, L, Cheadle, J, Easton, D, Dunlop, M, Houlston, R, Spurdle, A, Tomlinson, I
Format: Journal article
Language:English
Published: Nature 2015

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