A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZs) has been shown to be protective against malaria, but the features of the antibody response induced by this treatment remain unclear. To investigate this response in detail, we isolated IgM and IgG monoclonal antibodies from Tanz...

Descripció completa

Dades bibliogràfiques
Autors principals:	Tan, J, Sack, B, Oyen, D, Zenklusen, I, Piccoli, L, Barbieri, S, Foglierini, M, Fregni, C, Marcandalli, J, Jongo, S, Abdulla, S, Perez, L, Corradin, G, Varani, L, Sallusto, F, Sim, B, Hoffman, S, Kappe, S, Daubenberger, C, Wilson, I, Lanzavecchia, A
Format:	Journal article
Idioma:	English
Publicat:	Springer Nature 2018

Ítems similars

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
per: Pieper, K, et al.
Publicat: (2017)

HCMV Envelope Glycoprotein Diversity Demystified
per: Mathilde Foglierini, et al.
Publicat: (2019-05-01)

AncesTree: An interactive immunoglobulin lineage tree visualizer.
per: Mathilde Foglierini, et al.
Publicat: (2020-07-01)

Sterile protection against malaria is independent of immune responses to the circumsporozoite protein.
per: Anne Charlotte Grüner, et al.
Publicat: (2007-12-01)

Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein
per: Gladys J. Keitany, et al.
Publicat: (2016-12-01)

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
per: Tan, J, et al.
Publicat: (2015)

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
per: Aschenbrenner, D, et al.
Publicat: (2018)

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
per: David Oyen, et al.
Publicat: (2020-03-01)

Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.
per: Cate Speake, et al.
Publicat: (2016-01-01)

Correction: Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.
per: C Speake, et al.
Publicat: (2016-01-01)

Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses.
per: Nathaniel J Schuldt, et al.
Publicat: (2011-01-01)

Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy
per: Carlota Dobaño, et al.
Publicat: (2019-05-01)

Variation in the circumsporozoite protein of Plasmodium falciparum: vaccine development implications.
per: Kavita Gandhi, et al.
Publicat: (2014-01-01)

The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial.
per: Régine Audran, et al.
Publicat: (2009-10-01)

Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein
per: Min Zhang, et al.
Publicat: (2017-08-01)

Rational engineering of a human anti-dengue antibody through experimentally validated computational docking.
per: Luca Simonelli, et al.
Publicat: (2013-01-01)

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity.
per: Michela Perotti, et al.
Publicat: (2020-12-01)

Probing novel epitopes on the Plasmodium falciparum circumsporozoite protein for vaccine development
per: Krenger, PS, et al.
Publicat: (2024)

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium
per: Ferguson, D, et al.
Publicat: (2014)

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats
per: Iga Kucharska, et al.
Publicat: (2022-01-01)

Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias
per: Saralamba, N, et al.
Publicat: (2018)

Protective efficacy of peptides from Plasmodium vivax circumsporozoite protein
per: Atcheson, E, et al.
Publicat: (2020)

Immune evasion in malaria: altered peptide ligands of the circumsporozoite protein.
per: Plebanski, M, et al.
Publicat: (1997)

Circumsporozoite Surface Protein-based malaria vaccines: a review
per: Maria Edilene Martins de Almeida, et al.
Publicat: (2021-01-01)

Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
per: Mauricio M. Rodrigues, et al.
Publicat: (1991-06-01)

Malaria oocysts require circumsporozoite protein to evade mosquito immunity
per: Feng Zhu, et al.
Publicat: (2022-06-01)

A Comprehensive Analysis of Plasmodium Circumsporozoite Protein Binding to Hepatocytes.
per: Jinghua Zhao, et al.
Publicat: (2016-01-01)

Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions.
per: Nagesh R Aragam, et al.
Publicat: (2013-01-01)

Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers
per: Fergal J. Duffy, et al.
Publicat: (2021-07-01)

The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01 E
per: Ali, MS, et al.
Publicat: (2025)

Probing novel epitopes on the Plasmodium falciparum circumsporozoite protein for vaccine development
per: Pascal S. Krenger, et al.
Publicat: (2024-11-01)

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.
per: David J P Ferguson, et al.
Publicat: (2014-01-01)

An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein
per: Lucie Jelínková, et al.
Publicat: (2021-01-01)

Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax
per: Tuấn Cường Võ, et al.
Publicat: (2020-09-01)

Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11
per: Iga Kucharska, et al.
Publicat: (2020-11-01)

Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania
per: Tobias Schindler, et al.
Publicat: (2019-04-01)

Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody
per: Manuela C Aguirre-Botero, et al.
Publicat: (2025-02-01)

Rationale for Further Development of a Vaccine Based on the Circumsporozoite Protein of Plasmodium vivax.
per: Anjali Yadava, et al.
Publicat: (2017-01-01)

Genetic Diversity and Natural Selection of the Plasmodium knowlesi Circumsporozoite Protein Nonrepeat Regions.
per: Mun Yik Fong, et al.
Publicat: (2015-01-01)

Exit of Plasmodium sporozoites from oocysts is an active process that involves the circumsporozoite protein.
per: Qian Wang, et al.
Publicat: (2005-09-01)