Kinetic and in vivo analysis of the soluble IGF2 receptor

Kinetic and in vivo analysis of the soluble IGF2 receptor

Manylion Llyfryddiaeth
Prif Awduron:	Morrice, J, Groeger, G, Brown, M, Barclay, A, Graham, C, Hassan, A
Fformat:	Journal article
Cyhoeddwyd:	2000

Eitemau Tebyg

Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor: the effects of domain 13 and pH.
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Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.
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The soluble IGF2 receptor reduces small intestine adenoma number in the Apc(Min/+) mouse
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Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor.
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Structure and functional analysis of the IGF-II/IGF2R interaction.
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The Association of Soluble IGF2R and IGF2R Gene Polymorphism with Type 2 Diabetes
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Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues.
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Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells.
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Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes.
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Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.
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Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.
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Development of molecular agents for IGF receptor targeting.
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Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
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The IGF receptor as anticancer treatment target.
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Targeting the IGF receptor as treatment for cancer
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How IGF-1 activates its receptor
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Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
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Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype
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A novel binding site for the human insulin-like growth factor-II (IGF-II)/mannose 6-phosphate receptor on IGF-II.
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Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance data.
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Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling
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Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.
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Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.
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IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
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AFFINITY AND KINETIC-ANALYSIS OF THE INTERACTION OF THE CELL-ADHESION MOLECULE CD2 WITH ITS LIGANDS CD48 AND CD58
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Characterization data of gilthead sea bream (Sparus aurata) IGF-I receptors (IGF-IRa/Rb)
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An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
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Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis
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Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression
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Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway.
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Insulin like growth factor 2 (Igf2) and its receptor gene (Igf2r) showed opposite expression in diploid parthenogenetic embryos in Capra hircus
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Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype.
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The EGF receptor interacts with the type 1 IGF receptor and regulates its stability.
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Soluble interleukin-2 receptors in ulcerative colitis
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Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes
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Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells.
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A role for CIM6P/IGF2 receptor in memory consolidation and enhancement
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