The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Dent's disease is a nephrolithiasis disorder associated with hypercalciuria and low molecular weight proteinuria that is caused by mutations in the voltage-gated chloride channel ClC-5. Because the exact cause of hypercalciuria in this disease is unknown and could come from a renal, intestinal,...
Egile Nagusiak: | Silva, I, Cebotaru, V, Wang, H, Wang, X, Wang, S, Guo, G, Devuyst, O, Thakker, R, Guggino, W, Guggino, SE |
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Formatua: | Journal article |
Hizkuntza: | English |
Argitaratua: |
2003
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Antzeko izenburuak
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Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.
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