The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Dent's disease is a nephrolithiasis disorder associated with hypercalciuria and low molecular weight proteinuria that is caused by mutations in the voltage-gated chloride channel ClC-5. Because the exact cause of hypercalciuria in this disease is unknown and could come from a renal, intestinal,...
Príomhchruthaitheoirí: | Silva, I, Cebotaru, V, Wang, H, Wang, X, Wang, S, Guo, G, Devuyst, O, Thakker, R, Guggino, W, Guggino, SE |
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Formáid: | Journal article |
Teanga: | English |
Foilsithe / Cruthaithe: |
2003
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Míreanna comhchosúla
Míreanna comhchosúla
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Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.
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Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease.
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