Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.

Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.

Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the only known cause of developmental speech and language disorders in humans. To date, there are no known targets of human FOXP2 in the nervous system. The identification of FOXP2 targets in the developing human...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Spiteri, E, Konopka, G, Coppola, G, Bomar, J, Oldham, M, Ou, J, Vernes, S, Fisher, S, Ren, B, Geschwind, D
التنسيق:	Journal article
اللغة:	English
منشور في:	2007

مواد مشابهة

High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders.
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FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.
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Identification of foxp2 truncation as a novel cause of developmental speech disorder.
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Molecular windows into speech and language disorders.
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The structure of innate vocalizations in Foxp2-deficient mouse pups.
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DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility
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