Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.

Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.

OBJECTIVE: In a previous study, we identified a 50-kDa G3-containing aggrecan degradation product in bovine cartilage, released from the tissue after interleukin-1 (IL-1) stimulation in the presence of oncostatin M (OSM). Our objective was to purify, determine the N-terminal sequence of this fragme...

ver descrição completa

Detalhes bibliográficos
Main Authors:	Durigova, M, Soucy, P, Fushimi, K, Nagase, H, Mort, J, Roughley, P
Formato:	Journal article
Idioma:	English
Publicado em:	2008

Registos relacionados

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.
Por: Durigova, M, et al.
Publicado em: (2011)

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
Por: M Durigova, et al.
Publicado em: (2011-01-01)

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
Por: Durigova, M, et al.
Publicado em: (2011)

The role of aggrecan in normal and osteoarthritic cartilage
Por: Peter J Roughley, et al.
Publicado em: (2014-01-01)

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage
Por: P Roughley, et al.
Publicado em: (2006-01-01)

Isolation of fibronectin fragments that induce aggrecan degradation in cartilage
Por: Sofat, N, et al.
Publicado em: (2006)

Fibronectin fragments induce aggrecan degradation in human cartilage and are increased in osteoarthritic cartilage
Por: Sofat, N, et al.
Publicado em: (2007)

Aggrecan breakdown in cartilage induced by proteolytic fragments of fibronectin: implications in osteoarthritis
Por: Nagase, H
Publicado em: (2009)

The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism
Por: PJ Roughley, et al.
Publicado em: (2014-09-01)

Identifying synovial tissue-derived catabolic factors of cartilage aggrecan
Por: Rana, F, et al.
Publicado em: (2013)

Aggrecan structure in amphibian cartilage
Por: Covizi D.Z., et al.
Publicado em: (2000-01-01)

Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage
Por: Ng, Laurel Jean
Publicado em: (2006)

What is the minimal length of calcium pentosan polysulfate that is able to block aggrecan breakdown in cartilage?
Por: Troeberg, L, et al.
Publicado em: (2009)

Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains
Por: Lee, Hsu-Yi, et al.
Publicado em: (2015)

JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis.
Por: Ismail, H, et al.
Publicado em: (2015)

Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.
Por: Tibor T Glant, et al.
Publicado em: (2016-01-01)

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
Por: Fushimi, K, et al.
Publicado em: (2008)

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
Por: Yamamoto, K, et al.
Publicado em: (2013)

Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue
Por: Lee, Hsu-Yi
Publicado em: (2010)

Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
Por: Sondergaard Bodil-Cecilie, et al.
Publicado em: (2009-12-01)

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
Por: Troeberg, L, et al.
Publicado em: (2009)

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells
Por: W Richter, et al.
Publicado em: (2012-05-01)

Feprazone Ameliorates TNF-α-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS‑5 Signaling Pathway
Por: Xiaoyang Xiong, et al.
Publicado em: (2021-03-01)

Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration
Por: Naoki Ishiguro, et al.
Publicado em: (2009-10-01)

Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
Por: Didangelos, A, et al.
Publicado em: (2009)

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
Por: Roman J. Krawetz, et al.
Publicado em: (2022-05-01)

Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells
Por: Fontanil, T, et al.
Publicado em: (2017)

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
Por: Lim, N, et al.
Publicado em: (2010)

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage
Por: Takuya Tajima, et al.
Publicado em: (2017-11-01)

Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs
Por: Dan Luo, et al.
Publicado em: (2018-01-01)

Growth factors that drive aggrecan synthesis in healthy articular cartilage. Role for transforming growth factor-β?
Por: Peter M. van der Kraan, et al.
Publicado em: (2024-06-01)

The structure and function of cartilage proteoglycans
Por: P J Roughley
Publicado em: (2006-11-01)

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity
Por: Anthony J Hayes, et al.
Publicado em: (2020-08-01)

Matrix-bound growth factors are released upon cartilage compression by an aggrecan-dependent sodium flux that is lost in osteoarthritis
Por: Keppie, SJ, et al.
Publicado em: (2021)

Transforming the major autoantibody site on ADAMTS13: spacer domain variants retaining von Willebrand factor cleavage activity
Por: Marie Scully
Publicado em: (2020-11-01)

Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice
Por: Dan Yi, et al.
Publicado em: (2024-07-01)

ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
Por: Meng-Die Li, et al.
Publicado em: (2024-03-01)

Characterization of conformation-sensitive antibodies to ADAMTS13, the von Willebrand cleavage protease.
Por: Zuben E Sauna, et al.
Publicado em: (2009-08-01)

Engineering and expression of ADAMTS-4 and ADAMTS-5, proteolytic enzymes involved in osteoarthritis progression
Por: Lauer-Fields, J, et al.
Publicado em: (2005)

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
Por: Gendron, C, et al.
Publicado em: (2007)