Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.

Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.

OBJECTIVE: In a previous study, we identified a 50-kDa G3-containing aggrecan degradation product in bovine cartilage, released from the tissue after interleukin-1 (IL-1) stimulation in the presence of oncostatin M (OSM). Our objective was to purify, determine the N-terminal sequence of this fragme...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Durigova, M, Soucy, P, Fushimi, K, Nagase, H, Mort, J, Roughley, P
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2008

Ижил төстэй зүйлс

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.
-н: Durigova, M, зэрэг
Хэвлэсэн: (2011)

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
-н: M Durigova, зэрэг
Хэвлэсэн: (2011-01-01)

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
-н: Durigova, M, зэрэг
Хэвлэсэн: (2011)

The role of aggrecan in normal and osteoarthritic cartilage
-н: Peter J Roughley, зэрэг
Хэвлэсэн: (2014-01-01)

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage
-н: P Roughley, зэрэг
Хэвлэсэн: (2006-01-01)

Isolation of fibronectin fragments that induce aggrecan degradation in cartilage
-н: Sofat, N, зэрэг
Хэвлэсэн: (2006)

Fibronectin fragments induce aggrecan degradation in human cartilage and are increased in osteoarthritic cartilage
-н: Sofat, N, зэрэг
Хэвлэсэн: (2007)

Aggrecan breakdown in cartilage induced by proteolytic fragments of fibronectin: implications in osteoarthritis
-н: Nagase, H
Хэвлэсэн: (2009)

The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism
-н: PJ Roughley, зэрэг
Хэвлэсэн: (2014-09-01)

Identifying synovial tissue-derived catabolic factors of cartilage aggrecan
-н: Rana, F, зэрэг
Хэвлэсэн: (2013)

Aggrecan structure in amphibian cartilage
-н: Covizi D.Z., зэрэг
Хэвлэсэн: (2000-01-01)

Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage
-н: Ng, Laurel Jean
Хэвлэсэн: (2006)

What is the minimal length of calcium pentosan polysulfate that is able to block aggrecan breakdown in cartilage?
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2009)

Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains
-н: Lee, Hsu-Yi, зэрэг
Хэвлэсэн: (2015)

JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis.
-н: Ismail, H, зэрэг
Хэвлэсэн: (2015)

Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.
-н: Tibor T Glant, зэрэг
Хэвлэсэн: (2016-01-01)

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
-н: Fushimi, K, зэрэг
Хэвлэсэн: (2008)

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
-н: Yamamoto, K, зэрэг
Хэвлэсэн: (2013)

Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue
-н: Lee, Hsu-Yi
Хэвлэсэн: (2010)

Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
-н: Sondergaard Bodil-Cecilie, зэрэг
Хэвлэсэн: (2009-12-01)

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
-н: Troeberg, L, зэрэг
Хэвлэсэн: (2009)

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells
-н: W Richter, зэрэг
Хэвлэсэн: (2012-05-01)

Feprazone Ameliorates TNF-α-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS‑5 Signaling Pathway
-н: Xiaoyang Xiong, зэрэг
Хэвлэсэн: (2021-03-01)

Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration
-н: Naoki Ishiguro, зэрэг
Хэвлэсэн: (2009-10-01)

Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
-н: Didangelos, A, зэрэг
Хэвлэсэн: (2009)

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
-н: Roman J. Krawetz, зэрэг
Хэвлэсэн: (2022-05-01)

Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells
-н: Fontanil, T, зэрэг
Хэвлэсэн: (2017)

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
-н: Lim, N, зэрэг
Хэвлэсэн: (2010)

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage
-н: Takuya Tajima, зэрэг
Хэвлэсэн: (2017-11-01)

Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs
-н: Dan Luo, зэрэг
Хэвлэсэн: (2018-01-01)

Growth factors that drive aggrecan synthesis in healthy articular cartilage. Role for transforming growth factor-β?
-н: Peter M. van der Kraan, зэрэг
Хэвлэсэн: (2024-06-01)

The structure and function of cartilage proteoglycans
-н: P J Roughley
Хэвлэсэн: (2006-11-01)

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity
-н: Anthony J Hayes, зэрэг
Хэвлэсэн: (2020-08-01)

Matrix-bound growth factors are released upon cartilage compression by an aggrecan-dependent sodium flux that is lost in osteoarthritis
-н: Keppie, SJ, зэрэг
Хэвлэсэн: (2021)

Transforming the major autoantibody site on ADAMTS13: spacer domain variants retaining von Willebrand factor cleavage activity
-н: Marie Scully
Хэвлэсэн: (2020-11-01)

Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice
-н: Dan Yi, зэрэг
Хэвлэсэн: (2024-07-01)

ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
-н: Meng-Die Li, зэрэг
Хэвлэсэн: (2024-03-01)

Characterization of conformation-sensitive antibodies to ADAMTS13, the von Willebrand cleavage protease.
-н: Zuben E Sauna, зэрэг
Хэвлэсэн: (2009-08-01)

Engineering and expression of ADAMTS-4 and ADAMTS-5, proteolytic enzymes involved in osteoarthritis progression
-н: Lauer-Fields, J, зэрэг
Хэвлэсэн: (2005)

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
-н: Gendron, C, зэрэг
Хэвлэсэн: (2007)