MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD+-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic d...

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Bibliographic Details
Main Authors: Marjanović, M, Hurtado-Bagès, S, Lassi, M, Valero, V, Malinverni, R, Delage, H, Navarro, M, Corujo, D, Guberovic, I, Douet, J, Gama-Perez, P, Garcia-Roves, P, Ahel, I, Ladurner, A, Yanes, O, Bouvet, P, Suelves, M, Teperino, R, Pospisilik, J, Buschbeck, M
Format: Journal article
Language:English
Published: Nature Publishing Group 2017

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