Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003
Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-gr...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2014
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| _version_ | 1826278682578124800 |
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| author | Patrick, K Wade, R Goulden, N Mitchell, C Moorman, A Rowntree, C Jenkinson, S Hough, R Vora, A |
| author_facet | Patrick, K Wade, R Goulden, N Mitchell, C Moorman, A Rowntree, C Jenkinson, S Hough, R Vora, A |
| author_sort | Patrick, K |
| collection | OXFORD |
| description | Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally. © 2014 John Wiley and Sons Ltd. |
| first_indexed | 2024-03-06T23:47:36Z |
| format | Journal article |
| id | oxford-uuid:717c73f4-ed9e-46c1-9009-4a8cc951af9c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:47:36Z |
| publishDate | 2014 |
| publisher | Blackwell Publishing Ltd |
| record_format | dspace |
| spelling | oxford-uuid:717c73f4-ed9e-46c1-9009-4a8cc951af9c2022-03-26T19:43:53ZOutcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:717c73f4-ed9e-46c1-9009-4a8cc951af9cEnglishSymplectic Elements at OxfordBlackwell Publishing Ltd2014Patrick, KWade, RGoulden, NMitchell, CMoorman, ARowntree, CJenkinson, SHough, RVora, ASummary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally. © 2014 John Wiley and Sons Ltd. |
| spellingShingle | Patrick, K Wade, R Goulden, N Mitchell, C Moorman, A Rowntree, C Jenkinson, S Hough, R Vora, A Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003 |
| title | Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003 |
| title_full | Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003 |
| title_fullStr | Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003 |
| title_full_unstemmed | Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003 |
| title_short | Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003 |
| title_sort | outcome for children and young people with early t cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol ukall 2003 |
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