Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma

Protein arginine methyltransferase 5 (PRMT5) is over‐expressed in a wide variety of cancers and is implicated as having a key oncogenic role, achieved in part through its control of the master transcription regulator E2F1. We investigated the relevance of PRMT5 and E2F1 in neuroblastoma (NB) and fou...

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Bibliografiske detaljer
Main Authors: Bate‐Eya, LT, Albayrak, G, Carr, SM, Shrestha, A, Kanapin, A, Samsonova, A, La Thangue, NB
Format: Journal article
Sprog:English
Udgivet: Wiley Open Access 2024