Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma

Protein arginine methyltransferase 5 (PRMT5) is over‐expressed in a wide variety of cancers and is implicated as having a key oncogenic role, achieved in part through its control of the master transcription regulator E2F1. We investigated the relevance of PRMT5 and E2F1 in neuroblastoma (NB) and fou...

Полное описание

Библиографические подробности
Главные авторы: Bate‐Eya, LT, Albayrak, G, Carr, SM, Shrestha, A, Kanapin, A, Samsonova, A, La Thangue, NB
Формат: Journal article
Язык:English
Опубликовано: Wiley Open Access 2024