SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
We investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulation of multiple SARS-CoV-2 lineages over time, which were linked to multiple importations and...
| Автори: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Springer Nature
2021
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| _version_ | 1826278695538524160 |
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| author | Giovanetti, M Cella, E Benedetti, F Rife Magalis, B Fonseca, V Fabris, S Campisi, G Ciccozzi, A Angeletti, S Borsetti, A Tambone, V Sagnelli, C Pascarella, S Riva, A Ceccarelli, G Marcello, A Azarian, T Wilkinson, E de Oliveira, T Alcantara, LCJ Cauda, R Caruso, A Dean, NE Browne, C Lourenco, J Salemi, M Zella, D Ciccozzi, M |
| author_facet | Giovanetti, M Cella, E Benedetti, F Rife Magalis, B Fonseca, V Fabris, S Campisi, G Ciccozzi, A Angeletti, S Borsetti, A Tambone, V Sagnelli, C Pascarella, S Riva, A Ceccarelli, G Marcello, A Azarian, T Wilkinson, E de Oliveira, T Alcantara, LCJ Cauda, R Caruso, A Dean, NE Browne, C Lourenco, J Salemi, M Zella, D Ciccozzi, M |
| author_sort | Giovanetti, M |
| collection | OXFORD |
| description | We investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulation of multiple SARS-CoV-2 lineages over time, which were linked to multiple importations and characterized by large transmission clusters concomitant with a high number of infections. Subsequent implementation of a three-phase nationwide lockdown strategy greatly reduced infection numbers and hospitalizations. Yet we present evidence of sustained viral spread among sporadic clusters acting as "hidden reservoirs" during summer 2020. Mathematical modelling shows that increased mobility among residents eventually catalyzed the coalescence of such clusters, thus driving up the number of infections and initiating a new epidemic wave. Our results suggest that the efficacy of public health interventions is, ultimately, limited by the size and structure of epidemic reservoirs, which may warrant prioritization during vaccine deployment. |
| first_indexed | 2024-03-06T23:47:47Z |
| format | Journal article |
| id | oxford-uuid:7189fad5-c01c-41f7-9bf3-ff4d747fb2a7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:47:47Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:7189fad5-c01c-41f7-9bf3-ff4d747fb2a72022-03-26T19:44:27ZSARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in ItalyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7189fad5-c01c-41f7-9bf3-ff4d747fb2a7EnglishSymplectic ElementsSpringer Nature2021Giovanetti, MCella, EBenedetti, FRife Magalis, BFonseca, VFabris, SCampisi, GCiccozzi, AAngeletti, SBorsetti, ATambone, VSagnelli, CPascarella, SRiva, ACeccarelli, GMarcello, AAzarian, TWilkinson, Ede Oliveira, TAlcantara, LCJCauda, RCaruso, ADean, NEBrowne, CLourenco, JSalemi, MZella, DCiccozzi, MWe investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulation of multiple SARS-CoV-2 lineages over time, which were linked to multiple importations and characterized by large transmission clusters concomitant with a high number of infections. Subsequent implementation of a three-phase nationwide lockdown strategy greatly reduced infection numbers and hospitalizations. Yet we present evidence of sustained viral spread among sporadic clusters acting as "hidden reservoirs" during summer 2020. Mathematical modelling shows that increased mobility among residents eventually catalyzed the coalescence of such clusters, thus driving up the number of infections and initiating a new epidemic wave. Our results suggest that the efficacy of public health interventions is, ultimately, limited by the size and structure of epidemic reservoirs, which may warrant prioritization during vaccine deployment. |
| spellingShingle | Giovanetti, M Cella, E Benedetti, F Rife Magalis, B Fonseca, V Fabris, S Campisi, G Ciccozzi, A Angeletti, S Borsetti, A Tambone, V Sagnelli, C Pascarella, S Riva, A Ceccarelli, G Marcello, A Azarian, T Wilkinson, E de Oliveira, T Alcantara, LCJ Cauda, R Caruso, A Dean, NE Browne, C Lourenco, J Salemi, M Zella, D Ciccozzi, M SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy |
| title | SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy |
| title_full | SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy |
| title_fullStr | SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy |
| title_full_unstemmed | SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy |
| title_short | SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy |
| title_sort | sars cov 2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in italy |
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