THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)]
Stereoselective alkylation of (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH2CH3] with bromomethyl-t-butyl sulphide, followed by oxidative decomplexation in the presence of L-proline t-butyl ester gave, after deprotection, (-)-Captopril enantiomerically and diastereomerically pure in an overall yield of 59%. © 1987...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1797075260911124480 |
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| author | Bashiardes, G Davies, S |
| author_facet | Bashiardes, G Davies, S |
| author_sort | Bashiardes, G |
| collection | OXFORD |
| description | Stereoselective alkylation of (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH2CH3] with bromomethyl-t-butyl sulphide, followed by oxidative decomplexation in the presence of L-proline t-butyl ester gave, after deprotection, (-)-Captopril enantiomerically and diastereomerically pure in an overall yield of 59%. © 1987. |
| first_indexed | 2024-03-06T23:47:56Z |
| format | Journal article |
| id | oxford-uuid:7197adca-639e-45af-b5e1-03d258070727 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:47:56Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:7197adca-639e-45af-b5e1-03d2580707272022-03-26T19:44:36ZTHE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)]Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7197adca-639e-45af-b5e1-03d258070727EnglishSymplectic Elements at Oxford1987Bashiardes, GDavies, SStereoselective alkylation of (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH2CH3] with bromomethyl-t-butyl sulphide, followed by oxidative decomplexation in the presence of L-proline t-butyl ester gave, after deprotection, (-)-Captopril enantiomerically and diastereomerically pure in an overall yield of 59%. © 1987. |
| spellingShingle | Bashiardes, G Davies, S THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)] |
| title | THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)] |
| title_full | THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)] |
| title_fullStr | THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)] |
| title_full_unstemmed | THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)] |
| title_short | THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)] |
| title_sort | asymmetric synthesis of captopril utilizing the iron chiral auxiliary eta 5 c5h5 fe co pph3 |
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