THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)]

THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)]

Stereoselective alkylation of (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH2CH3] with bromomethyl-t-butyl sulphide, followed by oxidative decomplexation in the presence of L-proline t-butyl ester gave, after deprotection, (-)-Captopril enantiomerically and diastereomerically pure in an overall yield of 59%. © 1987...

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Main Authors:	Bashiardes, G, Davies, S
Format:	Journal article
Language:	English
Published:	1987

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