Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla
<p>Rationale: Anorexia Nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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Springer Verlag
2016
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| _version_ | 1797075261307486208 |
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| author | Godlewska, B Pike, A Sharpley, A Ayton, A Park, R Cowen, P Emir, U |
| author_facet | Godlewska, B Pike, A Sharpley, A Ayton, A Park, R Cowen, P Emir, U |
| author_sort | Godlewska, B |
| collection | OXFORD |
| description | <p>Rationale: Anorexia Nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that AN may be associated with reductions in indices of brain glutamate; however at conventional field strengths (≤ 3 Tesla) it is difficult to separate glutamate from its precursor and metabolite, glutamine.</p> <p>Objectives: The objective of the present study was to use high field (7 Tesla) MRS to measure concentrations of glutamate, in three separate brain voxels, in women with AN.</p> <p>Methods: We studied 13 female participants with anorexia nervosa (AN) and 12 healthy female controls who underwent MRS scanning at 7 Tesla with voxels placed in anterior cingulate cortex, occipital cortex and putamen. Neurometabolites were calculated using the unsuppressed water signal as a reference and corrected for individual cerebrospinal fluid concentration in the voxel.</p> <p>Results: We found that participants with AN had significantly lower concentrations of glutamate in all three voxels (mean reduction 8%, p= 0.002) but glutamine levels were not altered. Concentrations of N-Acetyl-Aspartate, creatine, GABA and glutathione were also unchanged. However, inositol was lower in AN participants in anterior cingulate (p= 0.022) and occipital cortex (p= 0.002).</p> <p>Conclusions: Women with AN apparently have widespread reductions in brain glutamate. Further work will be needed to assess if this change has pathophysiological relevance orwhether it is a consequence of the many physical changes produced in AN by food restriction.</p> |
| first_indexed | 2024-03-06T23:47:56Z |
| format | Journal article |
| id | oxford-uuid:7197f6c5-8f84-4c87-9c04-4a4f2b87964e |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:47:56Z |
| publishDate | 2016 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | oxford-uuid:7197f6c5-8f84-4c87-9c04-4a4f2b87964e2022-03-26T19:44:38ZBrain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 TeslaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7197f6c5-8f84-4c87-9c04-4a4f2b87964eSymplectic Elements at OxfordSpringer Verlag2016Godlewska, BPike, ASharpley, AAyton, APark, RCowen, PEmir, U<p>Rationale: Anorexia Nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that AN may be associated with reductions in indices of brain glutamate; however at conventional field strengths (≤ 3 Tesla) it is difficult to separate glutamate from its precursor and metabolite, glutamine.</p> <p>Objectives: The objective of the present study was to use high field (7 Tesla) MRS to measure concentrations of glutamate, in three separate brain voxels, in women with AN.</p> <p>Methods: We studied 13 female participants with anorexia nervosa (AN) and 12 healthy female controls who underwent MRS scanning at 7 Tesla with voxels placed in anterior cingulate cortex, occipital cortex and putamen. Neurometabolites were calculated using the unsuppressed water signal as a reference and corrected for individual cerebrospinal fluid concentration in the voxel.</p> <p>Results: We found that participants with AN had significantly lower concentrations of glutamate in all three voxels (mean reduction 8%, p= 0.002) but glutamine levels were not altered. Concentrations of N-Acetyl-Aspartate, creatine, GABA and glutathione were also unchanged. However, inositol was lower in AN participants in anterior cingulate (p= 0.022) and occipital cortex (p= 0.002).</p> <p>Conclusions: Women with AN apparently have widespread reductions in brain glutamate. Further work will be needed to assess if this change has pathophysiological relevance orwhether it is a consequence of the many physical changes produced in AN by food restriction.</p> |
| spellingShingle | Godlewska, B Pike, A Sharpley, A Ayton, A Park, R Cowen, P Emir, U Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla |
| title | Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla |
| title_full | Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla |
| title_fullStr | Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla |
| title_full_unstemmed | Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla |
| title_short | Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla |
| title_sort | brain glutamate in anorexia nervosa a magnetic resonance spectroscopy case control study at 7 tesla |
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