Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.

The multidrug-resistant cancer cell lines NCI/AdR(RES) and MES-SA/DX-5 have higher glycolipid levels and higher P-glycoprotein expression than the chemosensitive cell lines MCF7-wt and MES-SA. Inhibiting glycolipid biosynthesis by blocking glucosylceramide synthase has been proposed to reverse drug...

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Bibliographic Details
Main Authors:	Norris-Cervetto, E, Callaghan, R, Platt, F, Dwek, R, Butters, T
Format:	Journal article
Language:	English
Published:	2004

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