TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes

TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes

Introduction Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo studies in transgenic mice have highlighted important...

Podrobná bibliografie
Hlavní autoři:	Verma, M, Loh, N, Sabaratnam, R, Vasan, S, Van Dam, A, Todorčević, M, Neville, M, Toledo, E, Karpe, F, Christodoulides, C
Médium:	Journal article
Jazyk:	English
Vydáno:	Elsevier 2022

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