Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.

Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth.

p53-dependent apoptosis is a major determinant of its tumor suppressor activity and can be triggered by hypoxia. No p53 target is known to be induced by p53 or to mediate p53-dependent apoptosis during hypoxia. We report that p53 can directly upregulate expression of Bnip3L, a cell death inducer. Du...

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Dades bibliogràfiques
Autors principals:	Fei, P, Wang, W, Kim, S, Wang, S, Burns, T, Sax, J, Buzzai, M, Dicker, D, Mckenna, W, Bernhard, E, El-Deiry, W
Format:	Journal article
Idioma:	English
Publicat:	2004

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