Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.
Neonatal encephalopathy (NE) is the clinical manifestation of disordered neonatal brain function. Lack of universal agreed definitions of NE and the sub-group with hypoxic-ischaemia (HIE) makes the estimation of incidence and the identification of risk factors problematic. NE incidence is estimated...
| Main Authors: | , , |
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| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
2010
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| _version_ | 1826278776391073792 |
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| author | Kurinczuk, J White-Koning, M Badawi, N |
| author_facet | Kurinczuk, J White-Koning, M Badawi, N |
| author_sort | Kurinczuk, J |
| collection | OXFORD |
| description | Neonatal encephalopathy (NE) is the clinical manifestation of disordered neonatal brain function. Lack of universal agreed definitions of NE and the sub-group with hypoxic-ischaemia (HIE) makes the estimation of incidence and the identification of risk factors problematic. NE incidence is estimated as 3.0 per 1000 live births (95%CI 2.7 to 3.3) and for HIE is 1.5 (95%CI 1.3 to 1.7). The risk factors for NE vary between developed and developing countries with growth restriction the strongest in the former and twin pregnancy in the latter. Potentially modifiable risk factors include maternal thyroid disease, receipt of antenatal care, infection and aspects of the management of labour and delivery, although indications for some interventions were not reported and may represent a response to fetal compromise rather than the cause. It is estimated that 30% of cases of NE in developed populations and 60% in developing populations have some evidence of intrapartum hypoxic-ischaemia. |
| first_indexed | 2024-03-06T23:49:01Z |
| format | Journal article |
| id | oxford-uuid:71f404f5-26e8-45a4-a743-ae6a57da96b7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:49:01Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:71f404f5-26e8-45a4-a743-ae6a57da96b72022-03-26T19:46:57ZEpidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:71f404f5-26e8-45a4-a743-ae6a57da96b7EnglishSymplectic Elements at Oxford2010Kurinczuk, JWhite-Koning, MBadawi, NNeonatal encephalopathy (NE) is the clinical manifestation of disordered neonatal brain function. Lack of universal agreed definitions of NE and the sub-group with hypoxic-ischaemia (HIE) makes the estimation of incidence and the identification of risk factors problematic. NE incidence is estimated as 3.0 per 1000 live births (95%CI 2.7 to 3.3) and for HIE is 1.5 (95%CI 1.3 to 1.7). The risk factors for NE vary between developed and developing countries with growth restriction the strongest in the former and twin pregnancy in the latter. Potentially modifiable risk factors include maternal thyroid disease, receipt of antenatal care, infection and aspects of the management of labour and delivery, although indications for some interventions were not reported and may represent a response to fetal compromise rather than the cause. It is estimated that 30% of cases of NE in developed populations and 60% in developing populations have some evidence of intrapartum hypoxic-ischaemia. |
| spellingShingle | Kurinczuk, J White-Koning, M Badawi, N Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. |
| title | Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. |
| title_full | Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. |
| title_fullStr | Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. |
| title_full_unstemmed | Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. |
| title_short | Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. |
| title_sort | epidemiology of neonatal encephalopathy and hypoxic ischaemic encephalopathy |
| work_keys_str_mv | AT kurinczukj epidemiologyofneonatalencephalopathyandhypoxicischaemicencephalopathy AT whitekoningm epidemiologyofneonatalencephalopathyandhypoxicischaemicencephalopathy AT badawin epidemiologyofneonatalencephalopathyandhypoxicischaemicencephalopathy |