Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information...
| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
BioMed Central
2014
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| _version_ | 1826278838779248640 |
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| author | White, N Ashley, E Recht, J Delves, M Ruecker, A Smithuis, F Eziefula, A Bousema, T Drakeley, C Chotivanich, K Imwong, M Pukrittayakamee, S Prachumsri, J Chu, C Andolina, C Bancone, G Hien, T Mayxay, M Taylor, W von Seidlein, L Price, R Barnes, K Djimdé, A ter Kuile, F Gosling, R Chen, I Dhorda, M Stepniewska, K Guérin, P Woodrow, C Dondorp, A Day, N Nosten, F |
| author_facet | White, N Ashley, E Recht, J Delves, M Ruecker, A Smithuis, F Eziefula, A Bousema, T Drakeley, C Chotivanich, K Imwong, M Pukrittayakamee, S Prachumsri, J Chu, C Andolina, C Bancone, G Hien, T Mayxay, M Taylor, W von Seidlein, L Price, R Barnes, K Djimdé, A ter Kuile, F Gosling, R Chen, I Dhorda, M Stepniewska, K Guérin, P Woodrow, C Dondorp, A Day, N Nosten, F |
| author_sort | White, N |
| collection | OXFORD |
| description | Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies. |
| first_indexed | 2024-03-06T23:49:56Z |
| format | Journal article |
| id | oxford-uuid:72435f19-8e28-4725-a93b-6fbabd4c808b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:49:56Z |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:72435f19-8e28-4725-a93b-6fbabd4c808b2022-03-26T19:48:57ZAssessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:72435f19-8e28-4725-a93b-6fbabd4c808bEnglishSymplectic Elements at OxfordBioMed Central2014White, NAshley, ERecht, JDelves, MRuecker, ASmithuis, FEziefula, ABousema, TDrakeley, CChotivanich, KImwong, MPukrittayakamee, SPrachumsri, JChu, CAndolina, CBancone, GHien, TMayxay, MTaylor, Wvon Seidlein, LPrice, RBarnes, KDjimdé, Ater Kuile, FGosling, RChen, IDhorda, MStepniewska, KGuérin, PWoodrow, CDondorp, ADay, NNosten, FIndirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies. |
| spellingShingle | White, N Ashley, E Recht, J Delves, M Ruecker, A Smithuis, F Eziefula, A Bousema, T Drakeley, C Chotivanich, K Imwong, M Pukrittayakamee, S Prachumsri, J Chu, C Andolina, C Bancone, G Hien, T Mayxay, M Taylor, W von Seidlein, L Price, R Barnes, K Djimdé, A ter Kuile, F Gosling, R Chen, I Dhorda, M Stepniewska, K Guérin, P Woodrow, C Dondorp, A Day, N Nosten, F Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. |
| title | Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. |
| title_full | Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. |
| title_fullStr | Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. |
| title_full_unstemmed | Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. |
| title_short | Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. |
| title_sort | assessment of therapeutic responses to gametocytocidal drugs in plasmodium falciparum malaria |
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