Crystal structures of penicillin-binding protein 3 from pseudomonas aeruginosa: Comparison of native and antibiotic-bound forms

We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas aeruginosa in native form and covalently linked to two important β-lactam antibiotics, carbenicillin and ceftazidime. Overall, the structures of apo and acyl complexes are very similar; however, vari...

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Bibliographic Details
Main Authors: Sainsbury, S, Bird, L, Rao, V, Shepherd, S, Stuart, D, Hunter, W, Owens, R, Ren, J
Format: Journal article
Language:English
Published: 2011