Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy.
Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription fac...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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| _version_ | 1797075445246590976 |
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| author | Begbie, J Wood, J Anderson, P Latchman, D |
| author_facet | Begbie, J Wood, J Anderson, P Latchman, D |
| author_sort | Begbie, J |
| collection | OXFORD |
| description | Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU family transcription factor Oct-2 is known to be induced in sensory neurons by nerve growth factor (NGF) and might therefore be affected by the removal of target-derived NGF following axotomy. Paradoxically, however, the expression of Oct-2 showed a transient increase of two- to three-fold 24 h after axotomy. In contrast, axotomy had no effect on the levels of the Brn-3 sub-family of POU proteins, indicating that this effect was specific for Oct-2. |
| first_indexed | 2024-03-06T23:50:33Z |
| format | Journal article |
| id | oxford-uuid:72723f0f-a375-463e-81d5-79e1001f2cf9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:50:33Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:72723f0f-a375-463e-81d5-79e1001f2cf92022-03-26T19:50:14ZSpecific up-regulation of the POU domain transcription factor Oct-2 following axotomy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:72723f0f-a375-463e-81d5-79e1001f2cf9EnglishSymplectic Elements at Oxford1996Begbie, JWood, JAnderson, PLatchman, DPeripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU family transcription factor Oct-2 is known to be induced in sensory neurons by nerve growth factor (NGF) and might therefore be affected by the removal of target-derived NGF following axotomy. Paradoxically, however, the expression of Oct-2 showed a transient increase of two- to three-fold 24 h after axotomy. In contrast, axotomy had no effect on the levels of the Brn-3 sub-family of POU proteins, indicating that this effect was specific for Oct-2. |
| spellingShingle | Begbie, J Wood, J Anderson, P Latchman, D Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. |
| title | Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. |
| title_full | Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. |
| title_fullStr | Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. |
| title_full_unstemmed | Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. |
| title_short | Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy. |
| title_sort | specific up regulation of the pou domain transcription factor oct 2 following axotomy |
| work_keys_str_mv | AT begbiej specificupregulationofthepoudomaintranscriptionfactoroct2followingaxotomy AT woodj specificupregulationofthepoudomaintranscriptionfactoroct2followingaxotomy AT andersonp specificupregulationofthepoudomaintranscriptionfactoroct2followingaxotomy AT latchmand specificupregulationofthepoudomaintranscriptionfactoroct2followingaxotomy |