Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systema...

書誌詳細
主要な著者:	Lever, M, Lim, H, Kruger, P, Nguyen, J, Trendel, N, Abu-Shah, E, Maini, P, van der Merwe, P, Dushek, O
フォーマット:	Journal article
言語:	English
出版事項:	National Academy of Sciences 2016

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