Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
The spindle checkpoint protein Mad1 recruits Mad2 to unattached kinetochores and is essential for Mad2-Cdc20 complex formation in vivo but not in vitro. The crystal structure of the Mad1-Mad2 complex reveals an asymmetric tetramer, with elongated Mad1 monomers parting from a coiled-coil to form two...
Main Authors: | Sironi, L, Mapelli, M, Knapp, S, De Antoni, A, Jeang, K, Musacchio, A |
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Format: | Journal article |
Language: | English |
Published: |
2002
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