From the genetics of ankylosing spondylitis to new biology and drug target discovery

From the genetics of ankylosing spondylitis to new biology and drug target discovery

Genome-wide association studies (GWAS) have identified 113 single nucleotide polymorphisms (SNPs) affecting the risk of developing ankylosing spondylitis (AS), and an on-going GWAS study will likely identify 100+ new risk loci. The translation of genetic findings to novel disease biology and treatme...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Zaarour, N, Li, Y, Shi, H, Bowness, P, Chen, L
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Frontiers Media 2021

Eitemau Tebyg

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
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Cyhoeddwyd: (2012)

GM-CSF primes proinflammatory monocyte responses in Ankylosing Spondylitis
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Cyhoeddwyd: (2020)

The immunology of Ankylosing Spondylitis
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Cyhoeddwyd: (2011)

New developments in our understanding of Ankylosing Spondylitis pathogenesis
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Cyhoeddwyd: (2020)

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Cyhoeddwyd: (2012)

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Cyhoeddwyd: (2002)

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Cyhoeddwyd: (2004)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2003)

TARGETING MONOCYTE-EXPRESSED HLA-B27 HOMODIMERS IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2010)

TARGETING MONOCYTE-EXPRESSED HLA-B27 HOMODIMERS IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2010)

INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2012)

CHARACTERIZING TYPE 17 IMMUNE RESPONSES IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2013)

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
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Cyhoeddwyd: (2023)

Perspectives on the genetic associations of ankylosing spondylitis
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Cyhoeddwyd: (2021)

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Cyhoeddwyd: (2024)

THE GENETICS OF ERAP1 IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2010)

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AN INVESTIGATION INTO NECK PAIN, CLINICAL AND FUNCTIONAL INDICES, AND DRIVING IN ANKYLOSING SPONDYLITIS
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Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
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Cyhoeddwyd: (2018)

Incidence of total hip and knee replacement in UK patients with ankylosing spondylitis
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Cyhoeddwyd: (2018)

Incidence of total hip and knee replacement in UK patients with ankylosing spondylitis
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Cyhoeddwyd: (2018)

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Cyhoeddwyd: (2010-01-01)

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Cyhoeddwyd: (2013-12-01)

MASS SPECTROMETRY-BASED DETECTION AND QUANTITATION OF PUTATIVE BIOMARKERS FOR ANKYLOSING SPONDYLITIS
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Ankylosing spondylitis monocytes show upregulation of proteins involved in antigen presentation
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Cyhoeddwyd: (2008)

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Cyhoeddwyd: (2000)

Need for total hip and knee replacement in ankylosing spondylitis patients in England and Wales
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FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
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Drug Discovery in Spinal Cord Injury With Ankylosing Spondylitis Identified by Text Mining and Biomedical Databases
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THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2003)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
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Cyhoeddwyd: (2013)

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety.
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Cyhoeddwyd: (2005)

Heart damage in ankylosing spondylitis
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Cyhoeddwyd: (2009-08-01)

Utility of the modified stoke ankylosing spondylitis spine score (mSASSS)
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Cyhoeddwyd: (2008)