From the genetics of ankylosing spondylitis to new biology and drug target discovery

From the genetics of ankylosing spondylitis to new biology and drug target discovery

Genome-wide association studies (GWAS) have identified 113 single nucleotide polymorphisms (SNPs) affecting the risk of developing ankylosing spondylitis (AS), and an on-going GWAS study will likely identify 100+ new risk loci. The translation of genetic findings to novel disease biology and treatme...

Bibliográfalaš dieđut
Váldodahkkit:	Zaarour, N, Li, Y, Shi, H, Bowness, P, Chen, L
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Frontiers Media 2021

Geahča maid

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
Dahkki: Bowness, P
Almmustuhtton: (2012)

GM-CSF primes proinflammatory monocyte responses in Ankylosing Spondylitis
Dahkki: Shi, H, et al.
Almmustuhtton: (2020)

The immunology of Ankylosing Spondylitis
Dahkki: Bowness, P
Almmustuhtton: (2011)

New developments in our understanding of Ankylosing Spondylitis pathogenesis
Dahkki: Voruganti, A, et al.
Almmustuhtton: (2020)

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis.
Dahkki: Fischer, R, et al.
Almmustuhtton: (2012)

Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers
Dahkki: Ye Zhang, et al.
Almmustuhtton: (2024-05-01)

Genetics of ankylosing spondylitis
Dahkki: Karaderi, T
Almmustuhtton: (2012)

Genetics of ankylosing spondylitis.
Dahkki: Brown, M, et al.
Almmustuhtton: (2002)

Progress in our understanding of the pathogenesis of ankylosing spondylitis
Dahkki: Simone, D, et al.
Almmustuhtton: (2018)

Genetic susceptibility to ankylosing spondylitis.
Dahkki: Sims, A, et al.
Almmustuhtton: (2004)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Dahkki: Holden, W, et al.
Almmustuhtton: (2003)

TARGETING MONOCYTE-EXPRESSED HLA-B27 HOMODIMERS IN ANKYLOSING SPONDYLITIS
Dahkki: Bowness, P, et al.
Almmustuhtton: (2010)

TARGETING MONOCYTE-EXPRESSED HLA-B27 HOMODIMERS IN ANKYLOSING SPONDYLITIS
Dahkki: Bowness, P, et al.
Almmustuhtton: (2010)

INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 IN ANKYLOSING SPONDYLITIS
Dahkki: Chen, L, et al.
Almmustuhtton: (2012)

CHARACTERIZING TYPE 17 IMMUNE RESPONSES IN ANKYLOSING SPONDYLITIS
Dahkki: Al-Mossawi, H, et al.
Almmustuhtton: (2013)

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
Dahkki: Brown, AC, et al.
Almmustuhtton: (2023)

Perspectives on the genetic associations of ankylosing spondylitis
Dahkki: Wordsworth, BP, et al.
Almmustuhtton: (2021)

Investigating the genetics and immunopathogenesis of ankylosing spondylitis
Dahkki: Liu, F
Almmustuhtton: (2024)

THE GENETICS OF ERAP1 IN ANKYLOSING SPONDYLITIS
Dahkki: Wordsworth, B, et al.
Almmustuhtton: (2010)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
Dahkki: B. Paul Wordsworth, et al.
Almmustuhtton: (2021-03-01)

The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis
Dahkki: Tsui FW, et al.
Almmustuhtton: (2014-05-01)

AN INVESTIGATION INTO NECK PAIN, CLINICAL AND FUNCTIONAL INDICES, AND DRIVING IN ANKYLOSING SPONDYLITIS
Dahkki: Holden, W, et al.
Almmustuhtton: (2002)

Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
Dahkki: Hammitzsch, A, et al.
Almmustuhtton: (2018)

Incidence of total hip and knee replacement in UK patients with ankylosing spondylitis
Dahkki: Hawley, S, et al.
Almmustuhtton: (2018)

Incidence of total hip and knee replacement in UK patients with ankylosing spondylitis
Dahkki: Hawley, S, et al.
Almmustuhtton: (2018)

Ankylosing Spondylitis
Dahkki: Nazanin Ebrahimiadib, et al.
Almmustuhtton: (2021-07-01)

Ankylosing spondylitis
Dahkki: Mukesh Edavalath
Almmustuhtton: (2010-01-01)

ANKYLOSING SPONDYLITIS
Dahkki: I. V. Soldatenko
Almmustuhtton: (2013-12-01)

MASS SPECTROMETRY-BASED DETECTION AND QUANTITATION OF PUTATIVE BIOMARKERS FOR ANKYLOSING SPONDYLITIS
Dahkki: Fischer, R, et al.
Almmustuhtton: (2011)

Ankylosing spondylitis monocytes show upregulation of proteins involved in antigen presentation
Dahkki: Bowness, P, et al.
Almmustuhtton: (2008)

A proteomic approach to the identification of marker proteins for ankylosing spondylitis and rheumatoid arthritis
Dahkki: Wright, C, et al.
Almmustuhtton: (2005)

Susceptibility to ankylosing spondylitis.
Dahkki: Carter, N, et al.
Almmustuhtton: (2000)

Need for total hip and knee replacement in ankylosing spondylitis patients in England and Wales
Dahkki: Sacks, S, et al.
Almmustuhtton: (2017)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
Dahkki: Vecellio, M, et al.
Almmustuhtton: (2014)

Drug Discovery in Spinal Cord Injury With Ankylosing Spondylitis Identified by Text Mining and Biomedical Databases
Dahkki: Chenfeng Wang, et al.
Almmustuhtton: (2022-02-01)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
Dahkki: Timms, A, et al.
Almmustuhtton: (2003)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
Dahkki: Cohen, C, et al.
Almmustuhtton: (2013)

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety.
Dahkki: Holden, W, et al.
Almmustuhtton: (2005)

Heart damage in ankylosing spondylitis
Dahkki: A A Godzenko, et al.
Almmustuhtton: (2009-08-01)

Utility of the modified stoke ankylosing spondylitis spine score (mSASSS)
Dahkki: Wordsworth, P, et al.
Almmustuhtton: (2008)