Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

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Background: Mammalian oocyte activation occurs via a series of intracellular calcium (Ca 2) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ). There is now strong evidence to indicate that certain types of human male infertility are caused by failure of the sperm to...

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Bibliographic Details
Main Authors: Kashir, J, Jones, C, Lee, H, Rietdorf, K, Nikiforaki, D, Durrans, C, Ruas, M, Tee, S, Heindryckx, B, Galione, A, De Sutter, P, Fissore, R, Parrington, J, Coward, K
Format: Journal article
Language:English
Published: 2011

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