PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.

PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity against selected pathogens and in female fertility. Here, we report that the infertility of Ptx3(-/-) mice is associated with severe abnormalities of the cumulus oophorus and failure of in vivo, but not in vitro,...

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Main Authors: Salustri, A, Garlanda, C, Hirsch, E, De Acetis, M, Maccagno, A, Bottazzi, B, Doni, A, Bastone, A, Mantovani, G, Beck Peccoz, P, Salvatori, G, Mahoney, D, Day, A, Siracusa, G, Romani, L, Mantovani, A
Format: Journal article
Language:English
Published: 2004