Asymmetric synthesis of (-)-(R)-sitagliptin

Asymmetric synthesis of (-)-(R)-sitagliptin

Показать другие версии (2)

The asymmetric synthesis of (-)-(R)-sitagliptin was achieved in seven steps from commercially available starting materials using the highly diastereoselective conjugate additions of either lithium (R)-N-benzyl-N- (α-methylbenzyl)amide or lithium (R)-N-benzyl-N-(α-methyl-p- methoxybenzyl)amide to ter...

Полное описание

Библиографические подробности
Главные авторы:	Davies, S, Fletcher, A, Lv, L, Roberts, P, Thomson, J
Формат:	Journal article
Опубликовано:	2012

Схожие документы

Asymmetric synthesis of (-)-(R)-sitagliptin
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric synthesis of (-)-(R)-sitagliptin
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric synthesis of (-)-(1R,7aS)-absouline
по: Davies, S, и др.
Опубликовано: (2013)

Asymmetric synthesis of (-)-(1R,7aS)-absouline
по: Davies, S, и др.
Опубликовано: (2013)

Asymmetric synthesis of beta-fluoroaryl-beta-amino acids
по: Davies, S, и др.
Опубликовано: (2012)

Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate
по: Haoling Gao, и др.
Опубликовано: (2018-06-01)

Asymmetric synthesis of the tetraponerine alkaloids
по: Davies, S, и др.
Опубликовано: (2017)

Asymmetric synthesis of (-)-martinellic acid.
по: Davies, S, и др.
Опубликовано: (2013)

(-)-(2S,3R,Z)-Nakinadine A: first asymmetric synthesis and absolute configuration assignment.
по: Davies, S, и др.
Опубликовано: (2014)

Asymmetric synthesis of d-fagomine and its diastereoisomers
по: Davies, S, и др.
Опубликовано: (2018)

An efficient asymmetric synthesis of (-)-lupinine.
по: Davies, S, и др.
Опубликовано: (2014)

(-)-Pseudodistomin E: First asymmetric synthesis and absolute configuration assignment
по: Davies, S, и др.
Опубликовано: (2017)

Asymmetric synthesis of pyrrolizidines, indolizidines and quinolizidines via a double reductive cyclisation protocol
по: Davies, S, и др.
Опубликовано: (2017)

Asymmetric syntheses of (2R,3S)-3-hydroxyproline and (2S,3S)-3-hydroxyproline
по: Davies, S, и др.
Опубликовано: (2018)

Concise, efficient and highly selective asymmetric synthesis of (+)-(3S,4R)-cisapride
по: Davies, S, и др.
Опубликовано: (2011)

Concise, efficient and highly selective asymmetric synthesis of (+)-(3S,4R)-cisapride
по: Davies, S, и др.
Опубликовано: (2011)

Asymmetric synthesis of (-)-(S,S)-homaline
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric synthesis of (-)-(S,S)-homaline
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric synthesis of (-)-codonopsinine
по: Davies, S, и др.
Опубликовано: (2011)

Asymmetric synthesis of (-)-codonopsinine
по: Davies, S, и др.
Опубликовано: (2011)

Asymmetric synthesis of tetrahydrolipstatin and valilactone
по: Case-Green, S, и др.
Опубликовано: (2008)

Concise and highly selective asymmetric synthesis of acosamine from sorbic acid
по: Bagal, S, и др.
Опубликовано: (2011)

Concise and highly selective asymmetric synthesis of acosamine from sorbic acid
по: Bagal, S, и др.
Опубликовано: (2011)

Concise and highly selective asymmetric synthesis of acosamine from sorbic acid
по: Bagal, S, и др.
Опубликовано: (2011)

Polysubstituted piperidines via iodolactonization: application to the asymmetric synthesis of (+)-pseudodistomin D.
по: Davies, S, и др.
Опубликовано: (2012)

The asymmetric synthesis of (S,S)-methylphenidate hydrochloride via ring-opening of an enantiopure aziridinium intermediate with phenylmagnesium bromide
по: Davies, S, и др.
Опубликовано: (2019)

Asymmetric syntheses of fagomine and its stereoisomers
по: Davies, S, и др.
Опубликовано: (2019)

Asymmetric syntheses of the homalium alkaloids (-)-(S,S)-homaline and (-)-(R,R)-hopromine.
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric synthesis of the marine alkaloid (-)-(S)-nakinadine C
по: Davies, S, и др.
Опубликовано: (2013)

(-)-(S)-Nakinadine B: first asymmetric synthesis.
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric syntheses of (-)-isoretronecanol and (-)-trachelantamidine
по: Brambilla, M, и др.
Опубликовано: (2014)

Asymmetric synthesis of the allocolchicinoid natural product N-acetylcolchinol methyl ether (suhailamine), solid state and solution phase conformational analysis
по: Davies, S, и др.
Опубликовано: (2019)

Conjugate addition of lithium N-phenyl-N-(α-methylbenzyl)amide: application to the asymmetric synthesis of (R)-(-)-angustureine.
по: Bentley, SA, и др.
Опубликовано: (2011)

Asymmetric syntheses of (- )-hastanecine, (- )-turneforcidine and (- )-platynecine
по: Davies, S, и др.
Опубликовано: (2016)

Asymmetric syntheses of (-)-3-epi-Fagomine, (2R,3S,4R)-dihydroxypipecolic acid, and several polyhydroxylated homopipecolic acids.
по: Csatayová, K, и др.
Опубликовано: (2014)

Asymmetric syntheses of 3,4-syn- and 3,4-anti-3-substituted-4- aminopiperidin-2-ones: Application to the asymmetric synthesis of (+)-(3S,4R)-cisapride
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric syntheses of 3,4-syn- and 3,4-anti-3-substituted-4-aminopiperidin-2-ones: application to the asymmetric synthesis of (+)-(3S,4R)-cisapride
по: Davies, S, и др.
Опубликовано: (2012)

Asymmetric Synthesis of Piperidines and Octahydroindolizines
по: Davies, S, и др.
Опубликовано: (2010)

Asymmetric synthesis of (R)-sulcatol
по: Davies, S, и др.
Опубликовано: (1996)

Absolute configuration assignment by asymmetric syntheses of the homalium alkaloids (-)-(R,R,R)-hoprominol and (-)-(4'S,4″R,2‴R)-hopromalinol.
по: Davies, S, и др.
Опубликовано: (2012)