Asymmetric synthesis of (-)-(R)-sitagliptin
The asymmetric synthesis of (-)-(R)-sitagliptin was achieved in seven steps from commercially available starting materials using the highly diastereoselective conjugate additions of either lithium (R)-N-benzyl-N- (α-methylbenzyl)amide or lithium (R)-N-benzyl-N-(α-methyl-p- methoxybenzyl)amide to ter...
| Автори: | , , , , |
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| Формат: | Journal article |
| Опубліковано: |
2012
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