Physiological role of vascular endothelial growth factors as homeostatic regulators
The vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through their actions on vascular cells, but also through...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
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American Physiological Society
2018
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| _version_ | 1797075543048323072 |
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| author | Bates, DO Beazley-Long, N Benest, AV Ye, X Ved, N Hulse, RP Barratt, S Machado, MJ Donaldson, LF Harper, SJ Peiris-Pages, M Tortonese, DJ Oltean, S Foster, RR |
| author_facet | Bates, DO Beazley-Long, N Benest, AV Ye, X Ved, N Hulse, RP Barratt, S Machado, MJ Donaldson, LF Harper, SJ Peiris-Pages, M Tortonese, DJ Oltean, S Foster, RR |
| author_sort | Bates, DO |
| collection | OXFORD |
| description | The vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through their actions on vascular cells, but also through direct actions on other tissue types, including epithelial cells, neurons, and the immune system. The complexity of the five members of the gene family in terms of their different splice isoforms, differential translation, and specific localizations have enabled tissues to use these potent signaling molecules to control how they function to maintain their environment. This homeostatic function of VEGFs has been less intensely studied than their involvement in disease processes, development, and reproduction, but they still play a substantial and significant role in healthy control of blood volume and pressure, interstitial volume and drainage, renal and lung function, immunity, and signal processing in the peripheral and central nervous system. The widespread expression of VEGFs in healthy adult tissues, and the disturbances seen when VEGF signaling is inhibited support this view of the proteins as endogenous regulators of normal physiological function. This review summarizes the evidence and recent breakthroughs in understanding of the physiology that is regulated by VEGF, with emphasis on the role they play in maintaining homeostasis. |
| first_indexed | 2024-03-06T23:51:47Z |
| format | Journal article |
| id | oxford-uuid:72dbfd88-423d-47dc-aae2-e94a6a68c323 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:51:47Z |
| publishDate | 2018 |
| publisher | American Physiological Society |
| record_format | dspace |
| spelling | oxford-uuid:72dbfd88-423d-47dc-aae2-e94a6a68c3232022-03-26T19:52:43ZPhysiological role of vascular endothelial growth factors as homeostatic regulatorsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:72dbfd88-423d-47dc-aae2-e94a6a68c323Symplectic Elements at OxfordAmerican Physiological Society2018Bates, DOBeazley-Long, NBenest, AVYe, XVed, NHulse, RPBarratt, SMachado, MJDonaldson, LFHarper, SJPeiris-Pages, MTortonese, DJOltean, SFoster, RRThe vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through their actions on vascular cells, but also through direct actions on other tissue types, including epithelial cells, neurons, and the immune system. The complexity of the five members of the gene family in terms of their different splice isoforms, differential translation, and specific localizations have enabled tissues to use these potent signaling molecules to control how they function to maintain their environment. This homeostatic function of VEGFs has been less intensely studied than their involvement in disease processes, development, and reproduction, but they still play a substantial and significant role in healthy control of blood volume and pressure, interstitial volume and drainage, renal and lung function, immunity, and signal processing in the peripheral and central nervous system. The widespread expression of VEGFs in healthy adult tissues, and the disturbances seen when VEGF signaling is inhibited support this view of the proteins as endogenous regulators of normal physiological function. This review summarizes the evidence and recent breakthroughs in understanding of the physiology that is regulated by VEGF, with emphasis on the role they play in maintaining homeostasis. |
| spellingShingle | Bates, DO Beazley-Long, N Benest, AV Ye, X Ved, N Hulse, RP Barratt, S Machado, MJ Donaldson, LF Harper, SJ Peiris-Pages, M Tortonese, DJ Oltean, S Foster, RR Physiological role of vascular endothelial growth factors as homeostatic regulators |
| title | Physiological role of vascular endothelial growth factors as homeostatic regulators |
| title_full | Physiological role of vascular endothelial growth factors as homeostatic regulators |
| title_fullStr | Physiological role of vascular endothelial growth factors as homeostatic regulators |
| title_full_unstemmed | Physiological role of vascular endothelial growth factors as homeostatic regulators |
| title_short | Physiological role of vascular endothelial growth factors as homeostatic regulators |
| title_sort | physiological role of vascular endothelial growth factors as homeostatic regulators |
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