Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort
Background: Hormonal factors may influence risk for upper gastrointestinal cancers in women. We examined risk of oesophageal and gastric cancers in relation to reproductive factors in a large UK cohort, the Million Women Study. Methods: Among 1 319 409 women aged on average 56 years at recruitment,...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826278976035749888 |
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| author | Green, J Roddam, A Pirie, K Kirichek, O Reeves, G Beral, V |
| author_facet | Green, J Roddam, A Pirie, K Kirichek, O Reeves, G Beral, V |
| author_sort | Green, J |
| collection | OXFORD |
| description | Background: Hormonal factors may influence risk for upper gastrointestinal cancers in women. We examined risk of oesophageal and gastric cancers in relation to reproductive factors in a large UK cohort, the Million Women Study. Methods: Among 1 319 409 women aged on average 56 years at recruitment, 1186 incident cancers of the oesophagus and 1194 of the stomach were registered during 11.9 million person-years observation. Adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Results: Risks of both oesophageal and gastric cancer were significantly higher in postmenopausal than in pre-or peri-menopausal women (RRs 1.46, 1.07-2.00 and 1.59, 1.15-2.20, respectively; P≤0.01 for both); and, among postmenopausal women, risk was higher the younger women were at menopause (RR, 95% CI per 5 years younger at menopause 1.18, 1.05-1.34 for oesophageal cancer and 1.18, 1.04-1.34 for stomach cancer, P trend= 0.01 for both). For factors relating to childbearing, including women's age at first birth, their number of children, and breastfeeding history, the only significant association was a higher risk of oesophageal cancer in nulliparous, compared with parous, women (RR 1.31, 1.11-1.55; P=0.002). When risks for squamous cell and adenocarcinomas of the oesophagus were compared, most did not differ significantly, but statistical power was limited. Conclusion: Both oesophageal and gastric cancer risks appeared to be related to menopausal status and age at menopause, but there was little consistent evidence for associations with factors related to childbearing. © 2012 Cancer Research UK All rights reserved. |
| first_indexed | 2024-03-06T23:51:56Z |
| format | Journal article |
| id | oxford-uuid:72e6fb7e-f603-48f4-a8fd-34d08b3f7928 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:51:56Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:72e6fb7e-f603-48f4-a8fd-34d08b3f79282022-03-26T19:53:04ZReproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:72e6fb7e-f603-48f4-a8fd-34d08b3f7928EnglishSymplectic Elements at Oxford2012Green, JRoddam, APirie, KKirichek, OReeves, GBeral, VBackground: Hormonal factors may influence risk for upper gastrointestinal cancers in women. We examined risk of oesophageal and gastric cancers in relation to reproductive factors in a large UK cohort, the Million Women Study. Methods: Among 1 319 409 women aged on average 56 years at recruitment, 1186 incident cancers of the oesophagus and 1194 of the stomach were registered during 11.9 million person-years observation. Adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Results: Risks of both oesophageal and gastric cancer were significantly higher in postmenopausal than in pre-or peri-menopausal women (RRs 1.46, 1.07-2.00 and 1.59, 1.15-2.20, respectively; P≤0.01 for both); and, among postmenopausal women, risk was higher the younger women were at menopause (RR, 95% CI per 5 years younger at menopause 1.18, 1.05-1.34 for oesophageal cancer and 1.18, 1.04-1.34 for stomach cancer, P trend= 0.01 for both). For factors relating to childbearing, including women's age at first birth, their number of children, and breastfeeding history, the only significant association was a higher risk of oesophageal cancer in nulliparous, compared with parous, women (RR 1.31, 1.11-1.55; P=0.002). When risks for squamous cell and adenocarcinomas of the oesophagus were compared, most did not differ significantly, but statistical power was limited. Conclusion: Both oesophageal and gastric cancer risks appeared to be related to menopausal status and age at menopause, but there was little consistent evidence for associations with factors related to childbearing. © 2012 Cancer Research UK All rights reserved. |
| spellingShingle | Green, J Roddam, A Pirie, K Kirichek, O Reeves, G Beral, V Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort |
| title | Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort |
| title_full | Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort |
| title_fullStr | Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort |
| title_full_unstemmed | Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort |
| title_short | Reproductive factors and risk of oesophageal and gastric cancer in the Million Women Study cohort |
| title_sort | reproductive factors and risk of oesophageal and gastric cancer in the million women study cohort |
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