Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies

Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies

Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as...

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Bibliographic Details
Main Authors: Folegatti, P, Flaxman, A, Jenkin, D, Makinson, R, Kingham, L, Bellamy, D, Ramos Lopez, F, Sheridan, J, Poulton, I, Aboagye, J, Tran, N, Mitton, C, Roberts, R, Lawrie, A, Hill, A, Ewer, KJ, Gilbert, S
Format: Journal article
Language:English
Published: MDPI 2021
Description
Summary:Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.

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