Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies
Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2021
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| _version_ | 1826279010731032576 |
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| author | Folegatti, P Flaxman, A Jenkin, D Makinson, R Kingham, L Bellamy, D Ramos Lopez, F Sheridan, J Poulton, I Aboagye, J Tran, N Mitton, C Roberts, R Lawrie, A Hill, A Ewer, KJ Gilbert, S |
| author_facet | Folegatti, P Flaxman, A Jenkin, D Makinson, R Kingham, L Bellamy, D Ramos Lopez, F Sheridan, J Poulton, I Aboagye, J Tran, N Mitton, C Roberts, R Lawrie, A Hill, A Ewer, KJ Gilbert, S |
| author_sort | Folegatti, P |
| collection | OXFORD |
| description | Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses. |
| first_indexed | 2024-03-06T23:52:27Z |
| format | Journal article |
| id | oxford-uuid:73129aad-62df-4dd9-b268-0d95f94c3211 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:52:27Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:73129aad-62df-4dd9-b268-0d95f94c32112022-03-26T19:54:10ZSafety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspeciesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:73129aad-62df-4dd9-b268-0d95f94c3211EnglishSymplectic ElementsMDPI2021Folegatti, PFlaxman, AJenkin, DMakinson, RKingham, LBellamy, DRamos Lopez, FSheridan, JPoulton, IAboagye, JTran, NMitton, CRoberts, RLawrie, AHill, AEwer, KJGilbert, SHeterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses. |
| spellingShingle | Folegatti, P Flaxman, A Jenkin, D Makinson, R Kingham, L Bellamy, D Ramos Lopez, F Sheridan, J Poulton, I Aboagye, J Tran, N Mitton, C Roberts, R Lawrie, A Hill, A Ewer, KJ Gilbert, S Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies |
| title | Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies |
| title_full | Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies |
| title_fullStr | Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies |
| title_full_unstemmed | Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies |
| title_short | Safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies |
| title_sort | safety and immunogenicity of adenovirus and poxvirus vectored vaccines against a mycobacterium avium complex subspecies |
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