Artificial urinary bladder model
Technological advancements in the medical field are often slow and expensive, sometimes due to complexities associated with pre-clinical testing of medical devices and implants. There is therefore a growing need for new test beds that can mimic more closely the in vivo environment of physiological s...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
SAGE Publications
2024
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| _version_ | 1826313791412895744 |
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| author | Read, B Tan Sze Wuan, A Pietropaolo, A Somani, BK Carugo, D Mosayyebi, A |
| author_facet | Read, B Tan Sze Wuan, A Pietropaolo, A Somani, BK Carugo, D Mosayyebi, A |
| author_sort | Read, B |
| collection | OXFORD |
| description | Technological advancements in the medical field are often slow and expensive, sometimes due to complexities associated with pre-clinical testing of medical devices and implants. There is therefore a growing need for new test beds that can mimic more closely the in vivo environment of physiological systems. In the present study, a novel bladder model was designed and fabricated with the aim of providing a pre-clinical testing platform for urological stents and catheters. The model is collapsible, has a Young’s modulus that is comparable to a biological bladder, and can be actuated on-demand to enable voiding. Moreover, the developed fabrication technique provides versatility to adjust the model’s shape, size, and thickness, through a rapid and relatively inexpensive process. When compared to a biological bladder, there is a significant difference in compliance; however, the model exhibits cystometry profiles during priming and voiding that are qualitatively comparable to a biological bladder. The developed bladder model has therefore potential for future usage in urological device testing; however, improvements are required to more closely replicate the architecture and relevant flow metrics of a physiological bladder. |
| first_indexed | 2024-09-25T04:22:09Z |
| format | Journal article |
| id | oxford-uuid:73146ab9-fe9e-44d6-9926-0ce2affe850d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:22:09Z |
| publishDate | 2024 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:73146ab9-fe9e-44d6-9926-0ce2affe850d2024-08-12T19:35:26ZArtificial urinary bladder modelJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:73146ab9-fe9e-44d6-9926-0ce2affe850dEnglishJisc Publications RouterSAGE Publications2024Read, BTan Sze Wuan, APietropaolo, ASomani, BKCarugo, DMosayyebi, ATechnological advancements in the medical field are often slow and expensive, sometimes due to complexities associated with pre-clinical testing of medical devices and implants. There is therefore a growing need for new test beds that can mimic more closely the in vivo environment of physiological systems. In the present study, a novel bladder model was designed and fabricated with the aim of providing a pre-clinical testing platform for urological stents and catheters. The model is collapsible, has a Young’s modulus that is comparable to a biological bladder, and can be actuated on-demand to enable voiding. Moreover, the developed fabrication technique provides versatility to adjust the model’s shape, size, and thickness, through a rapid and relatively inexpensive process. When compared to a biological bladder, there is a significant difference in compliance; however, the model exhibits cystometry profiles during priming and voiding that are qualitatively comparable to a biological bladder. The developed bladder model has therefore potential for future usage in urological device testing; however, improvements are required to more closely replicate the architecture and relevant flow metrics of a physiological bladder. |
| spellingShingle | Read, B Tan Sze Wuan, A Pietropaolo, A Somani, BK Carugo, D Mosayyebi, A Artificial urinary bladder model |
| title | Artificial urinary bladder model |
| title_full | Artificial urinary bladder model |
| title_fullStr | Artificial urinary bladder model |
| title_full_unstemmed | Artificial urinary bladder model |
| title_short | Artificial urinary bladder model |
| title_sort | artificial urinary bladder model |
| work_keys_str_mv | AT readb artificialurinarybladdermodel AT tanszewuana artificialurinarybladdermodel AT pietropaoloa artificialurinarybladdermodel AT somanibk artificialurinarybladdermodel AT carugod artificialurinarybladdermodel AT mosayyebia artificialurinarybladdermodel |