EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

Dysregulation of the epigenome due to alterations in chromatin modifier proteins commonly contribute to malignant transformation. To interrogate the roles of epigenetic modifiers in cancer cells, we generated an epigenome-wide CRISPR-Cas9 knockout library (EPIKOL) that targets a wide-range of epigen...

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Bibliographic Details
Main Authors:	Yedier-Bayram, O, Gokbayrak, B, Kayabolen, A, Aksu, AC, Cavga, AD, Cingöz, A, Kala, EY, Karabiyik, G, Günsay, R, Esin, B, Morova, T, Uyulur, F, Syed, H, Philpott, M, Cribbs, AP, Kung, SHY, Lack, NA, Onder, TT, Bagci-Onder, T
Format:	Journal article
Language:	English
Published:	Springer Nature 2022

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